Łętocha Anna, Miastkowska Małgorzata, Sikora Elżbieta
Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, 31-155 Krakow, Poland.
Polymers (Basel). 2022 Sep 14;14(18):3834. doi: 10.3390/polym14183834.
Alginates are the most widely used natural polymers in the pharmaceutical, food and cosmetic industries. Usually, they are applied as a thickening, gel-forming and stabilizing agent. Moreover, the alginate-based formulations such as matrices, membranes, nanospheres or microcapsules are often used as delivery systems. Alginate microparticles (AMP) are biocompatible, biodegradable and nontoxic carriers, applied to encapsulate hydrophilic active substances, including probiotics. Here, we report the methods most frequently used for AMP production and encapsulation of different actives. The technological parameters important in the process of AMP preparation, such as alginate concentration, the type and concentration of other reagents (cross-linking agents, oils, emulsifiers and pH regulators), agitation speed or cross-linking time, are reviewed. Furthermore, the advantages and disadvantages of alginate microparticles as delivery systems are discussed, and an overview of the active ingredients enclosed in the alginate carriers are presented.
海藻酸盐是制药、食品和化妆品行业中使用最广泛的天然聚合物。通常，它们被用作增稠剂、凝胶形成剂和稳定剂。此外，基于海藻酸盐的制剂，如基质、膜、纳米球或微胶囊，常被用作递送系统。海藻酸盐微粒（AMP）是生物相容、可生物降解且无毒的载体，用于封装亲水性活性物质，包括益生菌。在此，我们报告了最常用于生产AMP和封装不同活性物质的方法。综述了在AMP制备过程中重要的技术参数，如海藻酸盐浓度、其他试剂（交联剂、油、乳化剂和pH调节剂）的类型和浓度、搅拌速度或交联时间。此外，还讨论了海藻酸盐微粒作为递送系统的优缺点，并概述了封装在海藻酸盐载体中的活性成分。
