巨细胞病毒阳性的溃疡性结肠炎患者抗病毒治疗效果不佳，可能是由于在荟萃分析中纳入研究不恰当所致。
Unfavorable outcome of antiviral therapy in cytomegalovirus-positive ulcerative colitis may be due to inappropriate study inclusion in meta-analysis.
作者信息
Wu Xiao-Wei, Yang Miao-Fang, Li Nan, Wang Fang-Yu
机构信息
Xiao-Wei Wu, Miao-Fang Yang, Nan Li, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
出版信息
World J Gastroenterol. 2015 Feb 7;21(5):1689-90. doi: 10.3748/wjg.v21.i5.1689.
Abstract
Some previous articles reported that antiviral treatment was effective to reduce the colectomy rate in ulcerative colitis (UC) patients with cytomegalovirus (CMV) infection. Kopylov et al recently carried out a systematic review and meta-analysis to evaluate the impact of antiviral therapy on CMV-positive UC. The results showed that patients who received antiviral treatment had a higher risk of 30-d colectomy. We found that in this meta-analysis, some studies were inappropriately included, leading to an unfavorable outcome of anti-CMV therapy in UC patients.
摘要
一些先前的文章报道，抗病毒治疗对于降低巨细胞病毒（CMV）感染的溃疡性结肠炎（UC）患者的结肠切除率是有效的。科皮洛夫等人最近进行了一项系统评价和荟萃分析，以评估抗病毒治疗对CMV阳性UC的影响。结果显示，接受抗病毒治疗的患者30天结肠切除风险更高。我们发现在这项荟萃分析中，一些研究被不恰当地纳入，导致UC患者抗CMV治疗出现了不良结果。
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