一种新型可视吸痰系统在犬模型中用于气管内吸痰很有用。

A novel visual sputum suctioning system is useful for endotracheal suctioning in a dog model.

作者信息

Liu Xun, Deng Huisheng, Huang Ziyang, Yan Bingbing, Lv Jingjing, Wu Jinxing

机构信息

Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, P.R. China.

Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, P.R. China.

出版信息

Int J Clin Exp Med. 2014 Dec 15;7(12):4819-27. eCollection 2014.

PMID:25663978

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4307425/

Abstract

OBJECTIVE

This study is to test the effectiveness of fiber-optic-guided endotracheal suction catheter (visual sputum suctioning system or VSSS) in dog models.

METHODS

Dog sputum models were established by administering dimethoate emulsifiable. Twenty-seven intubated dogs were equally randomized into three groups of conventional suctioning (CS) group, VSSS with no supplemental oxygen (VSSS) group and VSSS with 100% oxygen (VSSS/O2) group. The suctioning efficiency, vital signs and tracheal wall injury were assessed.

RESULTS

The VSSS/O2 (8.6 ± 0.7g) and VSSS groups (8.5 ± 0.9 g) collected significantly more sputum than the CS group (5.9 ± 0.8 g) (P < 0.05 for VSSS/O2 group versus CS group; P < 0.05 for VSSS group versus CS group). Immediately after suctioning, the arterial partial pressure of oxygen (PaO2 ) of VSSS/O2 group was significantly higher than that of the VSSS group or the CS group (both P < 0.05), and 5 min after suction the PaO2 , the mean arterial pressure (MAP) and heart rate (HR) in all groups returned to the baseline (p = 0.54, P = 0.67, P = 0.11, respectively). Moreover, in the VSSS/O2 and VSSS groups all the three variables were higher than the CS group at 5 min after suctioning (P < 0.01, P = 0.03; P = 0.02, P < 0.01; P = 0.02, P = 0.01 respectively).

CONCLUSIONS

Visual sputum suctioning system collected more sputum and caused less tracheal mucosa damage than conventional suctioning.

摘要

目的

本研究旨在测试光纤引导气管内吸痰导管（可视吸痰系统或VSSS）在犬模型中的有效性。

方法

通过给予乐果乳油建立犬痰液模型。将27只插管犬平均随机分为三组，即传统吸痰（CS）组、不补充氧气的VSSS组（VSSS）和补充100%氧气的VSSS组（VSSS/O2）。评估吸痰效率、生命体征和气管壁损伤情况。

结果

VSSS/O2组（8.6±0.7g）和VSSS组（8.5±0.9g）收集的痰液明显多于CS组（5.9±0.8g）（VSSS/O2组与CS组比较，P<0.05；VSSS组与CS组比较，P<0.05）。吸痰后即刻，VSSS/O2组的动脉血氧分压（PaO2）明显高于VSSS组或CS组（均P<0.05），吸痰后5分钟，所有组的PaO2、平均动脉压（MAP）和心率（HR）均恢复至基线水平（分别为p = 0.54、P = 0.67、P = 0.11）。此外，吸痰后5分钟时，VSSS/O2组和VSSS组的所有这三个变量均高于CS组（分别为P<0.01、P = 0.03；P = 0.02、P<0.01；P = 0.02、P = 0.01）。