Liu Zhixiang, Zhang Peisen, Dong Jie
Department of Nuclear Medicine, The Hospital Affiliated of Weifang Medical University Kuiwen Region 261031, Weifang City, Shandong Province, China.
Int J Clin Exp Med. 2014 Dec 15;7(12):5877-81. eCollection 2014.
Genetic factors play an important role in ankylosing spondylitis (AS) etiology and signal transducer and activator of transcription 4 (STAT4) gene polymorphisms may be involved. The aim of this study was to test whether STAT4 variants were associated with susceptibility to AS in a Chinese population.
A total of 175 subjects who were diagnosed as AS and 249 healthy age-matched controls were enrolled in the present study. The rs7574865 G/T SNP in STAT4 gene was genotyped in all the subjects. The SPSS software was used to investigate the association between the rs7574865 genotypes and AS susceptibility or severity.
Rs7574865 G/T was found to be significantly associated with increased risk and severity of AS.
Our data demonstrated the STAT4 rs7574865 G/T SNP was significantly associated with increased AS susceptibility and severity in Chinese Han Population.
遗传因素在强直性脊柱炎（AS）病因中起重要作用，信号转导和转录激活因子4（STAT4）基因多态性可能与之相关。本研究旨在检测在中国人群中STAT4基因变异是否与AS易感性相关。
本研究共纳入175例诊断为AS的患者和249例年龄匹配的健康对照。对所有受试者的STAT4基因rs7574865 G/T单核苷酸多态性进行基因分型。使用SPSS软件研究rs7574865基因型与AS易感性或严重程度之间的关联。
发现rs7574865 G/T与AS风险增加和严重程度显著相关。
我们的数据表明，在中国汉族人群中，STAT4 rs7574865 G/T单核苷酸多态性与AS易感性增加和严重程度显著相关。
