在中国汉族人群中，信号转导和转录激活因子4（STAT4）的基因变异与强直性脊柱炎的易感性和严重程度相关。
Genetic variants of STAT4 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population.
作者信息
Liu Zhixiang, Zhang Peisen, Dong Jie
机构信息
Department of Nuclear Medicine, The Hospital Affiliated of Weifang Medical University Kuiwen Region 261031, Weifang City, Shandong Province, China.
出版信息
Int J Clin Exp Med. 2014 Dec 15;7(12):5877-81. eCollection 2014.
Abstract
OBJECTIVE
Genetic factors play an important role in ankylosing spondylitis (AS) etiology and signal transducer and activator of transcription 4 (STAT4) gene polymorphisms may be involved. The aim of this study was to test whether STAT4 variants were associated with susceptibility to AS in a Chinese population.
METHODS
A total of 175 subjects who were diagnosed as AS and 249 healthy age-matched controls were enrolled in the present study. The rs7574865 G/T SNP in STAT4 gene was genotyped in all the subjects. The SPSS software was used to investigate the association between the rs7574865 genotypes and AS susceptibility or severity.
RESULTS
Rs7574865 G/T was found to be significantly associated with increased risk and severity of AS.
CONCLUSION
Our data demonstrated the STAT4 rs7574865 G/T SNP was significantly associated with increased AS susceptibility and severity in Chinese Han Population.
摘要
目的
遗传因素在强直性脊柱炎（AS）病因中起重要作用，信号转导和转录激活因子4（STAT4）基因多态性可能与之相关。本研究旨在检测在中国人群中STAT4基因变异是否与AS易感性相关。
方法
本研究共纳入175例诊断为AS的患者和249例年龄匹配的健康对照。对所有受试者的STAT4基因rs7574865 G/T单核苷酸多态性进行基因分型。使用SPSS软件研究rs7574865基因型与AS易感性或严重程度之间的关联。
结果
发现rs7574865 G/T与AS风险增加和严重程度显著相关。
结论
我们的数据表明，在中国汉族人群中，STAT4 rs7574865 G/T单核苷酸多态性与AS易感性增加和严重程度显著相关。
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2
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3
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