四种不同的B16小鼠黑色素瘤细胞亚系的行为：C57BL/6J皮肤。
Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin.
作者信息
Danciu Corina, Oprean Camelia, Coricovac Dorina E, Andreea Cioca, Cimpean Anca, Radeke Heinfried, Soica Codruta, Dehelean Cristina
机构信息
Department of Pharmacognosy, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
出版信息
Int J Exp Pathol. 2015 Apr;96(2):73-80. doi: 10.1111/iep.12114. Epub 2015 Feb 9.
Abstract
Transplantable murine melanomas are well-established models for the study of experimental cancer therapies. The aim of this study was to explore the behaviour of four different B16 murine melanoma cell sublines after inoculation into C57BL/6J mice; and, more specifically to analyse skin changes, with respect to two specific parameters: clinical (tumour volume, melanin amount, erythema) and histological (H & E, S100, VEGF expression). Both non-invasive and invasive analysis showed that B164A5 is the most aggressive melanoma cell line for C57BL/6J's skin, followed by B16F10 and then by diminished aggressive growth pattern by the B16GMCSF and B16FLT3 cell lines.
摘要
可移植性小鼠黑色素瘤是研究实验性癌症治疗的成熟模型。本研究的目的是探讨四种不同的B16小鼠黑色素瘤细胞亚系接种到C57BL/6J小鼠体内后的行为；更具体地说，是针对两个特定参数分析皮肤变化：临床参数（肿瘤体积、黑色素量、红斑）和组织学参数（苏木精和伊红染色、S100、血管内皮生长因子表达）。无创和有创分析均表明，B164A5是对C57BL/6J皮肤最具侵袭性的黑色素瘤细胞系，其次是B16F10，然后是B16GMCSF和B16FLT3细胞系，其侵袭性生长模式减弱。
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