Zhang Xueyan, He Hairong, Zhang Xu, Guo Wenjie, Wang Yueqi
Medical and Nursing School, Chengdu University , Chengdu , China.
Cancer Invest. 2015 Apr;33(4):121-5. doi: 10.3109/07357907.2014.1003934. Epub 2015 Feb 9.
Runt-related transcription factor 3 (RUNX3) has been reported to be a tumor-suppressing gene in hepatocellular carcinoma. Association between hepatocellular carcinoma and RUNX3 promoter methylation has been investigated in studies with specific ethnic backgrounds and small sample sizes. In this study, a meta-analysis was adopted to combine the data from 11 studies of association between RUNX3 promoter methylation and hepatocellular carcinoma. Pooled odds ratio for RUNX3 promoter methylation status in hepatocellular carcinoma versus control liver tissue was 24.37 (95%CI: 12.14, 48.92), p < .00001, indicates a strong association between methylation of the RUNX3 promoter and hepatocellular carcinoma.
据报道， runt相关转录因子3（RUNX3）是肝细胞癌中的一种肿瘤抑制基因。在具有特定种族背景和小样本量的研究中，已经对肝细胞癌与RUNX3启动子甲基化之间的关联进行了调查。在本研究中，采用荟萃分析来合并来自11项关于RUNX3启动子甲基化与肝细胞癌关联研究的数据。肝细胞癌与对照肝组织中RUNX3启动子甲基化状态的合并比值比为24.37（95%CI：12.14，48.92），p <.00001，表明RUNX3启动子甲基化与肝细胞癌之间存在强关联。
