细胞和组织功能障碍中的二羰基应激导致衰老和疾病。

Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.

作者信息

Rabbani Naila, Thornalley Paul J

机构信息

Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK.

出版信息

Biochem Biophys Res Commun. 2015 Mar 6;458(2):221-6. doi: 10.1016/j.bbrc.2015.01.140. Epub 2015 Feb 7.

DOI:10.1016/j.bbrc.2015.01.140

PMID:25666945

Abstract

Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protein and DNA modification contributing to cell and tissue dysfunction in ageing and disease. Enzymes metabolising dicarbonyls, glyoxalase 1 and aldoketo reductases, provide an efficient and stress-response enzyme defence against dicarbonyl stress. Dicarbonyl stress is produced by increased formation and/or decreased metabolism of dicarbonyl metabolites, and by exposure to exogenous dicarbonyls. It contributes to ageing, disease and activity of cytototoxic chemotherapeutic agents.

摘要

二羰基应激是二羰基代谢产物的异常蓄积，导致蛋白质和DNA修饰增加，从而在衰老和疾病过程中造成细胞和组织功能障碍。代谢二羰基的酶，如乙二醛酶1和醛酮还原酶，可提供一种有效的应激反应酶防御机制来抵御二羰基应激。二羰基应激是由二羰基代谢产物生成增加和/或代谢减少以及暴露于外源性二羰基物质所产生的。它与衰老、疾病以及细胞毒性化疗药物的活性有关。