Palmqvist Tomas, Dos S Matias Lucílio, Marthinsen Anne B L, Sundset Marit, Wanderås Anne D, Danielsen Signe, Toma-Dasu Iuliana
Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
Medical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden Department of Physics, Eduardo Mondlane University, Maputo, Mozambique
Anticancer Res. 2015 Feb;35(2):935-9.
To compare five inverse treatment plans with one conventional manually-optimized plan for cervical cancer brachytherapy (BT) using radiobiological parameters combined with dosimetric and volumetric parameters.
Five inverse treatment plans were calculated using an inverse planning simulated annealing (IPSA) algorithm for each of four fractions for 12 cervical cancer patients treated with high-dose-rate (HDR) brachytherapy. The inverse treatment plans were compared to a manually-optimized plan used for the actual treatment of the patients. The comparison of the plans was performed with respect to the probability of cure without complication (P+).
Overall, the manually optimized plan scored the best results; however, the probability of cure without complication is within an acceptable clinical range for all the plans.
Although there are still considerable uncertainties in the radiobiological parameters, the radiobiological plan evaluation method presents itself as a potential complement to physical dosimetric methods.
