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[关于连接基底神经节与犬脑嘴内侧被盖核的投射系统中信息传递的可能途径及其整合的分析]

[The analysis of the possible pathways of carrying information and its integration in the projection systems, connecting the basal ganglia with the rostromedial tegmental nucleus dog's brain].

作者信息

Gorbachevskaia A I

出版信息

Ross Fiziol Zh Im I M Sechenova. 2014 May;100(5):542-54.

Abstract

The structural foundation of processing of the information in the basal ganglia morphofunctional system was studied on the basis of the analysis of the projections between the separate parts of the rostral and thecaudal compartments of the rostromedial tegmental nucleus (RMTN) and the functionally different segments of the striatal and the pallidal structures, which were investigated by the method of the retrograde axonal transport. The elements of the topic, showing to opportunity of segregated carrying of the information between the limbic segments RMTN and the limbic striopallidal fields were revealed in the organization of the projections between the named structures in dog. But the convergence of the projection fibers, proceeding from the neurons of the functionally different parts of RMTN observed in the majority of striopallidal structures that testify about the opportunity of the integration of the functionally different information in them. The revealed labeled RMTN "reticular" neurons with sparsely branching dendrites and long axons, which are projected to the striopallidal structures, also testify about the integrative function of the investigated nucleus. The possible ways of carrying of the motor and the limbic information and its integration in the structures of the studied system and opportunity of the utilization of the received dates for making of the new models, which allow to understand better the mechanism of basal ganglia functioning in normal and pathological conditions are discussed.

摘要

在对嘴内侧被盖核(RMTN)吻侧和尾侧区各部分与纹状体和苍白球结构功能不同节段之间的投射进行逆行轴突运输法研究的基础上,对基底神经节形态功能系统中信息处理的结构基础进行了研究。在狗的上述结构之间的投射组织中,发现了主题元素,显示了在边缘节段RMTN和边缘纹状体苍白球区域之间分离携带信息的可能性。但在大多数纹状体苍白球结构中观察到,从RMTN功能不同部分的神经元发出的投射纤维会聚,这证明了在其中整合功能不同信息的可能性。所揭示的标记的RMTN“网状”神经元,其树突稀疏分支且轴突较长,投射到纹状体苍白球结构,也证明了所研究核的整合功能。讨论了运动和边缘信息的携带及其在研究系统结构中的整合的可能方式,以及利用所获得的数据制作新模型的可能性,这些新模型有助于更好地理解基底神经节在正常和病理条件下的功能机制。

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