Yasar Zehra, Acat Murat, Onaran Hilal, H Dincer Erhan, Cetinkaya Erdogan, A Korkmaz Nurdan, Ozgül Akif
Department of Chest Diseases, School of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
Department of Chest Diseases, School of Medicine, Karabuk University, Karabuk, Turkey.
Med Glas (Zenica). 2015 Feb;12(1):40-6.
18-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is an imaging modality that is often used to help differentiate benign from malignant pulmonary lesions and it has been shown to be more efficacious than conventional chest computed tomography (CT). However, some benign lesions may also show increased metabolic activity which can lead to false-positive PET findings. We aim to illustrate false positive findings of PET scan that simulate lung cancer in a variety of diseases.
Patients referred to Yedikule Chest Diseases and Surgery Teaching and Research Hospital with increased FDG uptake for which histological results were available over a 2-year period (2013-2014) were reviewed. Seven patients with false-positive PET/CT findings were reported in this study.
The majority of lesions showing increased metabolic activity were due to malignant diseases. However, increased 18 F-FDG uptake was also seen in benign lesions such as active pulmonary inflammation or infection, granulomatous processes and fibrotic lesions.
The integration of clinical history, morphologic findings of lesions on the CT component, and metabolic activities of PET/CT scan can help reduce false interpretations. Interventional procedures may be needed for tissue confirmation for differential diagnosis.
18-氟脱氧葡萄糖（FDG）正电子发射断层扫描-计算机断层扫描（PET/CT）是一种常用于帮助鉴别肺部良性与恶性病变的成像方式，且已证明其比传统胸部计算机断层扫描（CT）更有效。然而，一些良性病变也可能显示代谢活性增加，这可能导致PET检查结果出现假阳性。我们旨在阐述在多种疾病中模拟肺癌的PET扫描假阳性结果。
回顾了2013年至2014年期间转诊至耶迪库勒胸部疾病与外科教学与研究医院、FDG摄取增加且有组织学结果的患者。本研究报告了7例PET/CT检查结果为假阳性的患者。
大多数显示代谢活性增加的病变是由恶性疾病引起的。然而，在良性病变如活动性肺部炎症或感染、肉芽肿性病变和纤维化病变中也可见18F-FDG摄取增加。
结合临床病史、CT部分病变的形态学表现以及PET/CT扫描的代谢活性，有助于减少错误解读。鉴别诊断可能需要进行介入性操作以获取组织进行确认。
