[γ射线对甲醇溶液中地西泮的影响]
[The effect of gamma rays on medazepam in a methanolic solution].
作者信息
Werner I A, Altorfer H, Perlia X
出版信息
Pharm Acta Helv. 1989;64(4):98-115.
PMID:2567015
Abstract
Nine radiolytical products have been identified in a methanolic solution of Medazepam exposed to gamma-irradiation. A decomposition model taking into account these radiolytical products is presented. The formation of the individual radiolytical products can be deduced from analogous reactions of the radicals e-sdv., H, CH2OH, OH and HO2/O2- with several substances. Based on this knowledge of the radiochemical behaviour of Medazepam scavenger systems against radiolysis in solution can be developped.
摘要
在暴露于γ射线的美达西泮甲醇溶液中已鉴定出9种辐射分解产物。提出了一个考虑这些辐射分解产物的分解模型。各个辐射分解产物的形成可从自由基e-sdv.、H、CH2OH、OH和HO2/O2-与几种物质的类似反应推导得出。基于对美达西泮辐射化学行为的这种认识，可以开发出溶液中抗辐射分解的清除剂系统。
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