Kocher R, Markstaller R
Schweiz Rundsch Med Prax. 1989 May 2;78(18):520-3.
The convulsive effect of psychopharmaca depends on the 'epileptogenic' potency inherent to the substance, the sedation, the individual convulsion-threshold, epileptic disposition, paroxysmal EEG alterations, acute and chronic organic brain syndromes, alcoholism, high dosage, abrupt discontinuation of medication and forced onset of medication. The literature and the experience show convulsions to occur extremely rarely as a result of antidepressant and neuroleptic medication at standard doses. Caution is needed for patients at risk.
精神药物的惊厥作用取决于该物质固有的“致癫痫”效力、镇静作用、个体惊厥阈值、癫痫易感性、阵发性脑电图改变、急慢性器质性脑综合征、酒精中毒、高剂量、突然停药以及强制用药。文献和经验表明,标准剂量的抗抑郁药和抗精神病药极少导致惊厥。对有风险的患者需要谨慎。