Agid Y
Rev Prat. 1989 Mar 9;39(8):641-6.
The lesions of Parkinson's disease chiefly involve the dopaminergic nigrostriatal tract and the great subcortical-cortical dopaminergic, noradrenergic, serotoninergic and cholinergic neuron systems. On the basis of these data, one may suggest a mechanism for some motor and mental disorders, as well as the rationale for treatment with L-dopa, the origin of its main side-effects and the classical escape phenomenon observed with this drug.
帕金森病的病变主要累及多巴胺能黑质纹状体通路以及大脑皮层下-皮层的多巴胺能、去甲肾上腺素能、5-羟色胺能和胆碱能神经元系统。基于这些数据，可以推测一些运动和精神障碍的机制，以及左旋多巴治疗的理论依据、其主要副作用的起源和使用该药物时观察到的经典撤药现象。
