Flores Heather A, DuMont Vanessa L Bauer, Fatoo Aalya, Hubbard Diana, Hijji Mohammed, Barbash Daniel A, Aquadro Charles F
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853.
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853
G3 (Bethesda). 2015 Feb 9;5(4):583-92. doi: 10.1534/g3.114.015875.
Population genetic and comparative analyses in diverse taxa have shown that numerous genes involved in reproduction are adaptively evolving. Two genes involved in germline stem cell regulation, bag of marbles (bam) and benign gonial cell neoplasm (bgcn), have been shown previously to experience recurrent, adaptive evolution in both Drosophila melanogaster and D. simulans. Here we report a population genetic survey on eight additional genes involved in germline stem cell regulation in D. melanogaster and D. simulans that reveals all eight of these genes reject a neutral model of evolution in at least one test and one species after correction for multiple testing using a false-discovery rate of 0.05. These genes play diverse roles in the regulation of germline stem cells, suggesting that positive selection in response to several evolutionary pressures may be acting to drive the adaptive evolution of these genes.
对不同分类群的群体遗传学和比较分析表明，许多参与生殖的基因正在经历适应性进化。此前已表明，参与生殖系干细胞调控的两个基因，即“弹珠袋”基因（bam）和良性生殖细胞肿瘤基因（bgcn），在黑腹果蝇和拟暗果蝇中都经历了反复的适应性进化。在此，我们报告了一项针对黑腹果蝇和拟暗果蝇中另外八个参与生殖系干细胞调控的基因的群体遗传学调查，结果显示，在使用错误发现率为0.05进行多重检验校正后，所有这八个基因在至少一项检验和一个物种中都拒绝了中性进化模型。这些基因在生殖系干细胞调控中发挥着不同作用，这表明对几种进化压力的正选择可能正在推动这些基因的适应性进化。
