Banna N R, Jabbur S J
Faculty of Sciences, Lebanese University, Beirut, Lebanon.
Somatosens Mot Res. 1989;6(3):237-51. doi: 10.3109/08990228909144675.
The transmitter chemistry of the dorsal column nuclei is reviewed, with special emphasis on the monosynaptic component of the dorsal column-medial lemniscal pathway. It is maintained that in this anatomically addressed system concerned mainly with fast, secure sensory transmission, amino acids represent the predominant mechanism used for chemical relay of primary afferent impulses. The major excitatory primary afferent transmitter is most likely glutamic acid, whereas gamma-aminobutyric acid (GABA) fulfills adequately the role of transmitter of recurrent, postsynaptic and presynaptic inhibition. Recent immunohistochemical and physiological evidence indicates that 5-hydroxytryptamine, originating mainly from neurons of the raphé nuclei, plays a modulatory role in dorsal column transmission of innocuous sensory information. The basic synaptic elements involved in transmission across this relay, along with their corresponding chemical identities, are presented in the form of a speculative model.
本文综述了背柱核的递质化学，特别强调了背柱-内侧丘系通路的单突触成分。有人认为，在这个主要涉及快速、可靠感觉传递的解剖学相关系统中，氨基酸是初级传入冲动化学传递的主要机制。主要的兴奋性初级传入递质很可能是谷氨酸，而γ-氨基丁酸（GABA）充分发挥了回返性、突触后和突触前抑制的递质作用。最近的免疫组织化学和生理学证据表明，主要源自中缝核神经元的5-羟色胺在无害感觉信息的背柱传递中起调节作用。参与该中继传递的基本突触元件及其相应的化学特性以推测模型的形式呈现。
