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新药的并发症。

Complications of new medications.

作者信息

Roldan Carlos J, Paniagua Linda

机构信息

The University of Texas Health Science Center at Houston, Department of Emergency Medicine, Houston, Texas.

出版信息

West J Emerg Med. 2015 Jan;16(1):154-6. doi: 10.5811/westjem.2014.10.23837. Epub 2014 Nov 13.

DOI:10.5811/westjem.2014.10.23837
PMID:25671027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4307702/
Abstract

Numerous mandibular pathologies are diagnosed in the emergency department (ED). We present the case of a woman with severe right-sided mandibular pain who was found to have a pathological fracture and osteonecrosis of the jaw (ONJ). The etiology of ONJ was found to be associated to previous use of zoledronic acid to treat osteoporosis. The aim of this case report is to discuss the etiology, diagnosis and treatment of ONJ secondary to the use of zoledronic acid and to outline a clinical condition rarely seen in the ED whose incidence might rise with the increasing use of bisphosphonates.

摘要

急诊科诊断出许多下颌骨病变。我们报告一例右侧下颌骨剧痛的女性病例，该患者被发现患有病理性骨折和颌骨骨坏死（ONJ）。发现ONJ的病因与先前使用唑来膦酸治疗骨质疏松症有关。本病例报告的目的是讨论使用唑来膦酸继发ONJ的病因、诊断和治疗，并概述一种在急诊科很少见的临床情况，其发病率可能会随着双膦酸盐使用的增加而上升。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d8/4307702/90a4818064f5/wjem-16-154-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d8/4307702/90a4818064f5/wjem-16-154-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d8/4307702/90a4818064f5/wjem-16-154-g001.jpg

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Int J Surg Case Rep. 2018;51:318-322. doi: 10.1016/j.ijscr.2018.08.063. Epub 2018 Sep 10.

本文引用的文献

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Bisphosphonate-related osteonecrosis of the jaw (BRONJ) associated with a once-yearly IV infusion of zoledronic acid (Reclast) 5 mg: two cases and review of the literature.与每年静脉输注一次5毫克唑来膦酸（密固达）相关的双膦酸盐相关颌骨坏死（BRONJ）：两例病例及文献综述
Quintessence Int. 2014 Sep;45(8):685-90. doi: 10.3290/j.qi.a32242.
2
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J Oral Maxillofac Surg. 2010 Nov;68(11):2837-45. doi: 10.1016/j.joms.2010.07.017.
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Bisphosphonate-induced osteonecrosis of the jaw: a medical enigma?
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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Sep;108(3):e1-8. doi: 10.1016/j.tripleo.2009.04.027. Epub 2009 Jul 1.
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Ann Oncol. 2009 Jan;20(1):117-20. doi: 10.1093/annonc/mdn554. Epub 2008 Aug 9.
5
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J Bone Miner Res. 2008 Jun;23(6):826-36. doi: 10.1359/jbmr.080205.
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A different schedule of zoledronic acid can reduce the risk of the osteonecrosis of the jaw in patients with multiple myeloma.唑来膦酸的不同给药方案可降低多发性骨髓瘤患者颌骨坏死的风险。
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Ann Intern Med. 2006 May 16;144(10):753-61. doi: 10.7326/0003-4819-144-10-200605160-00009.
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