García Ruiz M L, Rodríguez Arnao M D, Lorenzo Navarro L, Mancheño Rico E, Teruel de Francisco M C, Gómez Pan A
Servicio de Pediatría, Hospital Gregorio Marañón, Madrid.
An Esp Pediatr. 1989 Mar;30(3):163-5.
We have compared the release of growth hormone (GH) after exercise (10 minutes pedaling on a fixed bicycle with ergometer), and two pharmacological alpha-adrenergic stimuli: clonidine (CL) or guanfacine (GU); in 36 prepuberal children whose height was below the third percentile. The tests were carried out in basal conditions, randomized and with a minimum interval of seven days between them. Blood GH was determined from cannulated antecubital veins. The results show a positive response (GH greater than 7 ng/ml) in 65.7% of cases after exercise, in 74.2% after CL and 71% after GU. The significant secondary effects observed after CL administration were sleepiness and decrease of arterial pressure. It is concluded that exercise is a useful test for assessing a possible deficiency of GH, and lacks significant side effects and that the diagnostic value of GU is similar to that of CL.
我们比较了运动（在带测力计的固定自行车上蹬踏10分钟）以及两种药理学α-肾上腺素能刺激剂：可乐定（CL）或胍法辛（GU）后生长激素（GH）的释放情况。研究对象为36名身高低于第三百分位数的青春期前儿童。测试在基础条件下进行，随机分组，且每次测试之间至少间隔7天。通过经肘前静脉置管采集血样测定GH。结果显示，运动后65.7%的病例出现阳性反应（GH大于7 ng/ml），CL给药后为74.2%，GU给药后为71%。CL给药后观察到的显著副作用为嗜睡和动脉压降低。结论是，运动是评估GH可能缺乏的一项有用测试，且无显著副作用，GU的诊断价值与CL相似。
