[Quinazolinones. 16. Synthesis and in vitro pharmacology of 2-aryl-1- ([3-(imidazol-4-yl)propyl]-guanidinylalkyl)-2,3-dihydro-4(1H)- quinazolinones].
作者信息
Büyüktimkin S, Buschauer A, Schunack W
出版信息
Arch Pharm (Weinheim). 1989 Feb;322(2):115-8. doi: 10.1002/ardp.19893220212.
PMID:2567156
Abstract
A series of 2-aryl-1- ([3-(imidazol-4-yl)propyl]guanidinylalkyl)-2,3-dihydro-4(1H)- quinazolinones were prepared starting with appropriate aminoalkyl-quinazolinones. The substances proved to be moderate H1-antagonists at the isolated guinea-pig ileum as well as H2-agonists, maximally achieving 1.6 times the activity of histamine at the isolated guinea-pig right atrium. Compounds with a three-membered carbon chain connecting the bicyclus and the guanidine system are up to 100 times more active at the atrium (chronotropic effect) than the corresponding lower homologues.
摘要
相似文献
1
[Quinazolinones. 16. Synthesis and in vitro pharmacology of 2-aryl-1- ([3-(imidazol-4-yl)propyl]-guanidinylalkyl)-2,3-dihydro-4(1H)- quinazolinones].
Arch Pharm (Weinheim). 1989 Feb;322(2):115-8. doi: 10.1002/ardp.19893220212.
2
[Quinazolinones. 18. Synthesis and H1/H2-antihistaminic action of omega-[2-aryl-2,3-dihydro-4(1H)-quinazolinone-1-yl]alkyl substituted ureas and cyanoguanidines].
Arch Pharm (Weinheim). 1991 May;324(5):291-5. doi: 10.1002/ardp.19913240507.
3
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
J Med Chem. 1989 Aug;32(8):1963-70. doi: 10.1021/jm00128a045.
4
[Synthesis and pharmacologic action of substituted imidazolyl- and thiazolylmethylthioethylguanidine].
Arzneimittelforschung. 1987 Sep;37(9):1003-7.
5
Synthesis of 3-[2-(2,3-dihydro-5-phenyl-4-substituted-3H-1,2,4- triazole-3-thione-2-yl)-acetylamino]-2-methyl-4(3H)-quinazolinones and their pharmacological activities.
Arch Pharm (Weinheim). 1989 Jan;322(1):49-51. doi: 10.1002/ardp.19893220112.
6
[Impromidine-analogous guanidines: synthesis and activity at the histamine H2-receptor. 29. Histamine analogs].
Arzneimittelforschung. 1988 Mar;38(3):327-32.
7
[Synthesis and pharmacologic action of arylmethylethylguanidines].
Arzneimittelforschung. 1987 Sep;37(9):1008-12.
8
[Racemic guanidinothiazoles with H2-antihistaminic activity. 13 H2-antihistaminics].
Arzneimittelforschung. 1983;33(3):377-80.
9
[Synthesis and h2-antihistaminic activity of n,n'-bisimidazole-substituted thioureas, cyanoguanidines and 2-nitro-1,1-ethenediamines 10. C: H2-antihistaminics].
Arzneimittelforschung. 1982;32(12):1509-12.
10
[Synthesis and combined H1-/H2 antagonist activity of mepyramine, pheniramine and cyclizine derivatives with cyanoguanidine, urea and nitroethenediamine partial structures].
Arch Pharm (Weinheim). 1994 Jul;327(7):455-62. doi: 10.1002/ardp.19943270708.
Zotero 插件