Mechanism of spontaneous loss of heat-stable toxin (STa) production in enterotoxigenic Escherichia coli.
作者信息
Sommerfelt H, Haukanes B I, Kalland K H, Svennerholm A M, Sanchéz J, Bjorvatn B
机构信息
Medical Department B, University of Bergen, Haukeland Hospital, Norway.
出版信息
APMIS. 1989 May;97(5):436-40. doi: 10.1111/j.1699-0463.1989.tb00812.x.
Abstract
Five strains of enterotoxigenic Escherichia coli (ETEC) showing spontaneous loss of heat-stable enterotoxin (STa) production were studied to elucidate the underlying genetic mechanisms. Southern blot analysis revealed that loss of STa production, and the corresponding lack of hybridization with the STa gene probes, were associated with deletions of DNA fragments harboring the relevant toxin genes rather than with loss of plasmids.
摘要
Zotero 插件