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CFA/I-ST质粒：O25、O63、O78和O128血清群产肠毒素大肠杆菌（ETEC）的比较以及从一株含R因子的流行ETEC分离株的转移

CFA/I-ST plasmids: comparison of enterotoxigenic Escherichia coli (ETEC) of serogroups O25, O63, O78, and O128 and mobilization from an R factor-containing epidemic ETEC isolate.

作者信息

Murray B E, Evans D J, Penãranda M E, Evans D G

出版信息

J Bacteriol. 1983 Jan;153(1):566-70. doi: 10.1128/jb.153.1.566-570.1983.

DOI:10.1128/jb.153.1.566-570.1983
PMID:6336743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC217412/
Abstract

Colonization factor antigen I (CFA/I) plays an important role in the pathogenesis of diarrhea due to enterotoxigenic Escherichia coli. In this study, we examined 11 CFA/I+ enterotoxigenic E. coli from serogroups O25, O63, O78, and O128 and found that with all strains, spontaneous loss of CFA/I was associated with the loss of heat-stable toxin (ST) and with the loss of a single plasmid ranging in size from 54 to 60 megadaltons; when heat-labile toxin was lost, this was associated with the loss of another plasmid. The R factor of one strain, TX432 (O78:H12:CFA/I+; ST+), was found to mobilize the CFA/I-ST plasmid into E. coli K-12 at a frequency of 20%. These studies provide further evidence that CFA/I production is plasmid mediated in enterotoxigenic E. coli belonging to serogroups O25, O63, O78, and O128.

摘要

定居因子抗原I（CFA/I）在产肠毒素大肠杆菌所致腹泻的发病机制中起重要作用。在本研究中，我们检测了来自O25、O63、O78和O128血清群的11株CFA/I+产肠毒素大肠杆菌，发现所有菌株中，CFA/I的自发丢失与热稳定毒素（ST）的丢失以及一个大小在54至60兆道尔顿之间的单一质粒的丢失有关；当不耐热毒素丢失时，这与另一个质粒的丢失有关。发现一株菌株TX432（O78:H12:CFA/I+; ST+）的R因子能以20%的频率将CFA/I-ST质粒转移到大肠杆菌K-12中。这些研究进一步证明，在属于O25、O63、O78和O128血清群的产肠毒素大肠杆菌中，CFA/I的产生是由质粒介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3d/217412/c039840adee5/jbacter00248-0590-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3d/217412/c039840adee5/jbacter00248-0590-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3d/217412/c039840adee5/jbacter00248-0590-a.jpg

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Plasmids coding for colonization factor antigen I and heat-stable enterotoxin production isolated from enterotoxigenic Escherichia coli: comparison of their properties.从产肠毒素大肠杆菌中分离出的编码定居因子抗原I和产热稳定肠毒素的质粒：其特性比较
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Plasmids coding for colonization factor antigens I and II, heat-labile enterotoxin, and heat-stable enterotoxin A2 in Escherichia coli.编码大肠杆菌中定居因子抗原I和II、不耐热肠毒素以及耐热肠毒素A2的质粒。
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