Gonçalves-Pereira João, Oliveira Bruno
Crit Care. 2014 Dec 19;18(6):695. doi: 10.1186/s13054-014-0695-6.
Dosing of antibiotics in critically ill patients is a significant challenge. The increasing number of patients undergoing extracorporeal membrane oxygenation further complicates the issue due to inflammatory activation and to drug sequestration in the circuit. Since patients receiving extracorporeal membrane oxygenation commonly face severe infections, appropriate antibiotic selection and correct dosing is of paramount importance to improve survival. Therapeutic drug monitoring (whenever available) or population pharmacokinetics, based on readily available clinical and laboratory data, should help tailor antibiotic dosing to the individual patient.
在重症患者中使用抗生素进行给药是一项重大挑战。由于炎症激活以及回路中的药物隔离，接受体外膜肺氧合的患者数量不断增加，这使得该问题更加复杂。由于接受体外膜肺氧合的患者通常面临严重感染，因此选择合适的抗生素并正确给药对于提高生存率至关重要。治疗药物监测（如有条件）或基于现成的临床和实验室数据的群体药代动力学，应有助于根据个体患者情况调整抗生素给药方案。
