Bunevicius Adomas, Iervasi Giorgio, Bunevicius Robertas
Department of Neurosurgery, Lithuanian University of Health Sciences, Eiveniu g. 2, LT-50009, Kaunas, Lithuania.
Expert Rev Neurother. 2015 Mar;15(3):315-26. doi: 10.1586/14737175.2015.1013465. Epub 2015 Feb 11.
Acute cerebrovascular disorders are common causes of death and disability worldwide. Prognostication of stroke victims rests mainly on admission clinical and radiological indexes of disease severity. Preclinical studies strongly suggest that thyroid hormones have a capacity to exert neuroprotective actions in the central nervous system under ischemic conditions via genomic and nongenomic actions. Low triiodothyronine (T3) syndrome affects 32-62% of patients following acute cerebrovascular events. Lower serum T3 concentrations are associated with greater stroke severity, more complicated clinical course, greater mortality rates and elevated risk for poor functional outcomes at discharge and long term. Further studies should address whether T3 can improve clinical stroke prognostication models. Studies investigating the neuroprotective role of thyroid hormone administration in acute cerebrovascular disease victims are encouraged.
急性脑血管疾病是全球范围内导致死亡和残疾的常见原因。中风患者的预后主要取决于入院时疾病严重程度的临床和影像学指标。临床前研究有力地表明，甲状腺激素在缺血条件下能够通过基因组和非基因组作用在中枢神经系统中发挥神经保护作用。低三碘甲状腺原氨酸（T3）综合征在急性脑血管事件后影响32%至62%的患者。较低的血清T3浓度与更严重的中风、更复杂的临床病程、更高的死亡率以及出院时和长期功能预后不良风险升高相关。进一步的研究应探讨T3是否能改善临床中风预后模型。鼓励开展研究以调查甲状腺激素给药在急性脑血管疾病患者中的神经保护作用。
