Zhang J, Zhang L N, Xia Y, Jin Y Y, Shen X X, Chen L J
Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
Zhonghua Xue Ye Xue Za Zhi. 2023 Mar 14;44(3):216-221. doi: 10.3760/cma.j.issn.0253-2727.2023.03.007.
This study aimed to examine the relationship between low T3 syndrome (LT3S) and the prognosis of newly diagnosed multiple myeloma (NDMM) patients. A retrospective examination of 211 NDMM patients treated at the Department of Hematology, Jiangsu Provincial People's Hospital from July 2009 to December 2020 was performed, and all patients received thyroid function testing to determine if they had LT3S. We investigated the relationship between LT3S and clinical features, as well as its impact on MM prognosis. Of the 211 patients, 119 were males, and 92 were females, with a median age of 60 (33-86) years. Patients with LT3S had significantly higher levels of β(2)-microglobulin, C-reactive protein, and blood creatinine compared to those with normal T3 levels. They also had lower levels of hemoglobin, platelets, and serum albumin, as well as more advanced ISS stages (<0.001) . Patients with LT3S had shorter progression-free survival (PFS) (16 months 30 months, =0.003) and overall survival (OS) (57 months 75 months, =0.004) than patients without LT3S. LT3S was found to be a standalone unfavorable factor in multivariate analysis, LT3S was an independent unfavorable factor in predicting both PFS (=2.114, 95% 1.271-3.516, =0.004) and OS (=2.231, 95% 1.088-4.577, =0.029) . Low T3 syndrome was an independent unfavorable prognostic predictor for NDMM.
本研究旨在探讨低T3综合征（LT3S）与新诊断的多发性骨髓瘤（NDMM）患者预后之间的关系。对2009年7月至2020年12月在江苏省人民医院血液科接受治疗的211例NDMM患者进行了回顾性研究，所有患者均接受甲状腺功能检测以确定是否患有LT3S。我们调查了LT3S与临床特征之间的关系，以及其对MM预后的影响。211例患者中，男性119例，女性92例，中位年龄为60（33 - 86）岁。与T3水平正常的患者相比，LT3S患者的β2-微球蛋白、C反应蛋白和血肌酐水平显著更高。他们的血红蛋白、血小板和血清白蛋白水平也更低，国际分期系统（ISS）分期更晚（<0.001）。与无LT3S的患者相比，LT3S患者的无进展生存期（PFS）更短（16个月对30个月，P = 0.003），总生存期（OS）也更短（57个月对75个月，P = 0.004）。在多因素分析中，LT3S被发现是一个独立的不良因素，LT3S是预测PFS（P = 2.114，95%CI 1.271 - 3.516，P = 0.004）和OS（P = 2.231，95%CI 1.088 - 4.577，P = 0.029）的独立不良因素。低T3综合征是NDMM的独立不良预后预测因素。
