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DeCoP,一项针对接受放疗的头颈癌患者使用中等吸收性手术垫的皮炎控制项目:一项回顾性分析。

DeCoP, a Dermatitis Control Program using a moderately absorbent surgical pad for head and neck cancer patients receiving radiotherapy: a retrospective analysis.

作者信息

Zenda Sadamoto, Ishi Shinobu, Akimoto Tetsuo, Arahira Satoko, Motegi Atsushi, Tahara Makoto, Hayashi Ryuichi, Asanuma Chie

机构信息

Division of Radiation Oncology, National Cancer Center Hospital East, Kashiwa

Division of Radiation Oncology, National Cancer Center Hospital East, Kashiwa.

出版信息

Jpn J Clin Oncol. 2015 May;45(5):433-8. doi: 10.1093/jjco/hyv010. Epub 2015 Feb 11.

Abstract

OBJECTIVE

We evaluated the clinical characteristics of a Dermatitis Control Program based on a moderately absorbent surgical pad for head and neck cancer patients undergoing (chemo)radiotherapy.

METHODS

We retrospectively reviewed patients who underwent definitive radiotherapy or post-operative radiotherapy and were treated during radiotherapy with a Dermatitis Control Program using a moderately absorbent surgical pad from May 2011 through April 2012. The main protocol was the 'Dermatitis Control Program', a systematic program which consists of a three-step ladder. When radiation dermatitis reached Grade 2, the irradiated area was covered with a moderately absorbent surgical pad. All outpatients and their families were instructed on how to cover and moisten the irradiated area. Radiation dermatitis was evaluated by physicians or nurses at an outpatient clinic and reviewed from photographs.

RESULTS

A total of 116 head and neck cancer patients were treated by definitive or adjuvant (chemo)radiotherapy in our hospital from May 2011 through April 2012. Of these, 85 patients managed their dermatitis using a new device and they were reviewed. Fifty-five patients received chemoradiotherapy, of whom 22 received induction chemotherapy before chemoradiotherapy. Median radiation dose at the onset of Grade 2 dermatitis was 60.0 Gy (range 40-71.2 Gy). Median time to recover from the end of radiotherapy was 10.5 days (range 0-25 days). The rate of recovery from Grade 2 dermatitis within 2 weeks after the end of radiotherapy was 89.4%. The rate of Grade 3 dermatitis was 7.1, with 6.7% in radiotherapy and 7.3% in chemoradiotherapy.

CONCLUSIONS

This study suggests that the DeCoP protocol with a moderately absorbent surgical pad might be useful for the treatment of radiation dermatitis in clinical practice.

摘要

目的

我们评估了一种基于中度吸水性手术垫的皮炎控制方案,用于接受(化疗)放疗的头颈癌患者的临床特征。

方法

我们回顾性分析了2011年5月至2012年4月期间接受根治性放疗或术后放疗,并在放疗期间使用中度吸水性手术垫进行皮炎控制方案治疗的患者。主要方案是“皮炎控制方案”,这是一个由三步阶梯组成的系统方案。当放射性皮炎达到2级时,用中度吸水性手术垫覆盖照射区域。所有门诊患者及其家属都接受了如何覆盖和湿润照射区域的指导。门诊由医生或护士对放射性皮炎进行评估,并通过照片进行复查。

结果

2011年5月至2012年4月期间,我院共有116名头颈癌患者接受了根治性或辅助性(化疗)放疗。其中,85名患者使用新设备处理皮炎并接受了复查。55名患者接受了放化疗,其中22名在放化疗前接受了诱导化疗。2级皮炎开始时的中位放疗剂量为60.0 Gy(范围40 - 71.2 Gy)。放疗结束后恢复的中位时间为10.5天(范围0 - 25天)。放疗结束后2周内2级皮炎的恢复率为89.4%。3级皮炎的发生率为7.1%,放疗患者中为6.7%,放化疗患者中为7.3%。

结论

本研究表明,采用中度吸水性手术垫的DeCoP方案在临床实践中可能有助于治疗放射性皮炎。

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