Papatheofanis F J, Papatheofanis B J
Department of Orthopaedics, College of Medicine, University of Illinois, Chicago 60680.
Int J Radiat Biol. 1989 Jun;55(6):1033-5. doi: 10.1080/09553008914551061.
Consideration of the biological effects of electromagnetic radiation is particularly important with regard to bone metabolism. Magnetic fields have been applied to the treatment of bone fractures, and similar fields are employed in the visualization of skeletal structures through magnetic resonance imaging (MRI). The present investigation addressed the effect of MRI-intensity (1 Tesla) magnetic fields on enzymatic indices of bone metabolism. Mice were exposed to intense static (direct current) magnetic fields for 30 min on each of 10 successive days. After this exposure regimen the primary spongiosum of the humerus was assayed for acid and alkaline phosphatase activity. No significant difference was detected in tissue levels of either enzyme in bones from control (n = 10), sham-exposed (n = 10), and magnetic field-exposed (n = 10) mice. These results suggested that the effects of magnetic field irradiation do not appear to involve modification of the activities of regulatory enzymes in bone.
考虑电磁辐射的生物效应对于骨代谢而言尤为重要。磁场已被应用于治疗骨折，并且类似的磁场通过磁共振成像（MRI）用于骨骼结构的可视化。本研究探讨了MRI强度（1特斯拉）磁场对骨代谢酶指标的影响。将小鼠连续10天每天暴露于强静态（直流电）磁场中30分钟。经过这种暴露方案后，对肱骨的初级海绵骨进行酸性和碱性磷酸酶活性测定。在对照（n = 10）、假暴露（n = 10）和磁场暴露（n = 10）小鼠的骨骼中，两种酶的组织水平均未检测到显著差异。这些结果表明，磁场照射的影响似乎不涉及骨中调节酶活性的改变。
