Cabral Katherine P, Ansell Jack E
Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY, USA.
Hofstra-North Shore/LIJ School of Medicine, Hempstead, NY, USA.
Vasc Health Risk Manag. 2015 Jan 30;11:117-23. doi: 10.2147/VHRM.S39726. eCollection 2015.
Three factor Xa inhibitors have been studied in the treatment of venous thromboembolism, both for acute therapy and as extended therapy to prevent recurrent events. Rivaroxaban, apixaban, and edoxaban have all proven to be effective in Phase III clinical trials for this indication when compared to current standard of therapy with similar or less bleeding. Nevertheless, the agents all offer different pharmacological profiles, which have an impact on patient selection and potential advantages in clinical practice.
三种Xa因子抑制剂已被研究用于静脉血栓栓塞的治疗,包括急性治疗以及作为预防复发事件的延长治疗。与目前具有相似或更少出血情况的标准治疗相比,利伐沙班、阿哌沙班和依度沙班在针对该适应症的III期临床试验中均已证明有效。然而,这些药物都具有不同的药理学特性,这对患者选择以及临床实践中的潜在优势产生影响。