Yang Ping, Li Liang, Kuang Weiping, Li Bo, Zhou Bin, Yang Jingjing, Huang Huiyong
Department of 3rd Neurosurgery, Brains Hospital of Hunan Province Changsha, China.
Institute of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine Changsha, China ; Department of Anatomy, Hunan University of Chinese Medicine Changsha, China.
Int J Clin Exp Pathol. 2014 Dec 1;7(12):9002-7. eCollection 2014.
Intracranial multiple germ cell tumors (GCTs) are rare. In this article, we reported a case of intracranial multiple GCTs in an 18-year-old boy with symptoms of psychosis for 8 months also. Tumors in the pineal, sellar region, corpus callosum, bilateral lateral ventricles and fourth ventricle were confirmed by enhanced magnetic resonance imaging (MRI) and stereotactic biopsy. Immunohistochemical analysis results demonstrated that the tumor cells were positive for CD117 and placental alkaline phosphatase (PLAP). The patient was treated by radiotherapy and the prescribed radiation doses were 18 Gy. After near 24 months of follow-up, no local recurrence and distant metastasis has been found.
颅内多发性生殖细胞肿瘤（GCTs）较为罕见。在本文中，我们报告了一例18岁男孩患有颅内多发性GCTs的病例，该男孩同时伴有8个月的精神病症状。通过增强磁共振成像（MRI）和立体定向活检确诊松果体区、鞍区、胼胝体、双侧侧脑室和第四脑室内存在肿瘤。免疫组织化学分析结果显示肿瘤细胞CD117和胎盘碱性磷酸酶（PLAP）呈阳性。该患者接受了放射治疗，规定的放射剂量为18 Gy。经过近24个月的随访，未发现局部复发和远处转移。
