性别很重要！胆碱能受体基因（CHRNA5）的性别与多态性相互作用会调节反应速度。

Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.

作者信息

Schneider Katja K, Hüle Lilian, Schote Andrea B, Meyer Jobst, Frings Christian

机构信息

Departments of aCognitive Psychology bNeurobehavioral Genetics, University of Trier, Trier, Germany.

出版信息

Neuroreport. 2015 Mar 4;26(4):186-91. doi: 10.1097/WNR.0000000000000313.

DOI:10.1097/WNR.0000000000000313

PMID:25674902

Abstract

Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.

摘要

乙酰胆碱会影响信息处理的速度。我们研究了rs3841324多态性（L/S）和rs16969968（G/A）多态性对斯特鲁普任务和负启动任务中反应速度的影响。这些多态性位于编码烟碱型乙酰胆碱受体α5亚基（CHRNA5）的基因中。rs3841324 S/S基因型和rs16969968 G/G基因型的男性携带者比至少携带一个L等位基因或一个A等位基因的男性携带者反应速度更快。相反，rs3841324 S/S基因型和rs16969968 G/G基因型的女性携带者比至少携带一个L等位基因或一个A等位基因的女性携带者反应速度更慢。这些结果表明，这两种多态性的次要等位基因以性别依赖、完全相反的方式调节反应速度。