滤泡辅助性 T 细胞（TFH）-IgA 应答可抑制微生物组。
TFH-IgA responses keep microbiota in check.
机构信息
Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; CREST, JST, Chiyoda-ku, Tokyo 102-0075, Japan.
出版信息
Cell Host Microbe. 2015 Feb 11;17(2):144-6. doi: 10.1016/j.chom.2015.01.009.
In this issue of Cell Host & Microbe, Kubinak et al. (2015) demonstrate that gut microbiota-mediated signaling through MyD88 in CD4+ T cells induces their differentiation into T follicular helper (TFH) cells that promote affinity-matured microbiota antigen-specific immunoglobulin A (IgA) responses. These TFH-driven IgA responses are essential for maintaining gut bacterial diversity and a healthy microbiota.
在本期《细胞宿主与微生物》中，Kubinak 等人（2015 年）证明了肠道微生物群通过 CD4+T 细胞中的 MyD88 进行信号传递，诱导其分化为滤泡辅助性 T 细胞（TFH），从而促进了亲和力成熟的微生物抗原特异性免疫球蛋白 A（IgA）应答。这些 TFH 驱动的 IgA 应答对于维持肠道细菌多样性和健康的微生物群至关重要。
Zotero 插件