Simcock Bryony, Narayan Kailash, Drummond Elizabeth, Bernshaw David, Wells Elizabeth, Hicks Rodney J
*Peter MacCallum Cancer Centre, Melbourne, Australia; and †Biostatistics and Computational Biology, Population Health, University of Otago, Christchurch, New Zealand.
Int J Gynecol Cancer. 2015 May;25(4):645-9. doi: 10.1097/IGC.0000000000000393.
The optimal method of assessing disease distribution in endometrial cancer is widely debated. Knowledge of disease distribution assists in planning adjuvant radiotherapy; in this study we used positron emission tomography/computed tomography (PET/CT) to assess disease distribution before radiotherapy.
Seventy-three consecutive patients referred to the Peter MacCallum Cancer Centre for adjuvant radiotherapy for endometrial cancer, with either high-risk disease after a hysterectomy or recurrent disease, had a PET/CT before treatment. The findings on PET/CT and clinical course were recorded.
PET/CT found additional disease in 35% of postoperative patients, changing planned treatment in 31%. In the group with known recurrence, additional disease was found in 72%, changing management in 36%.
PET/CT is a valuable tool for planning radiotherapy in endometrial cancer.
评估子宫内膜癌疾病分布的最佳方法存在广泛争议。了解疾病分布有助于辅助放疗的规划；在本研究中，我们使用正电子发射断层扫描/计算机断层扫描（PET/CT）在放疗前评估疾病分布。
连续73例因子宫内膜癌接受辅助放疗而转诊至彼得·麦卡勒姆癌症中心的患者，这些患者要么在子宫切除术后患有高危疾病，要么患有复发性疾病，在治疗前均接受了PET/CT检查。记录PET/CT的检查结果和临床病程。
PET/CT在35%的术后患者中发现了额外的病灶，使31%的患者治疗计划发生改变。在已知复发的患者组中，72%发现了额外的病灶，36%的患者治疗管理发生改变。
PET/CT是规划子宫内膜癌放疗的一种有价值的工具。
