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经皮转子成形术缓解双侧转子骨髓瘤溶解性病变患者的疼痛

Pain relief with percutaneous trochanteroplasty in a patient with bilateral trochanteric myelomatous lytic lesions.

作者信息

Wahezi Sayed E, Silva Kyle, Najafi Shervin

机构信息

Montefiore Medical Center /Albert Einstein College of Medicine, Bronx, NY.

出版信息

Pain Physician. 2015 Jan-Feb;18(1):E57-63.

Abstract

Multiple myeloma is a hematologic malignancy associated with destructive bone loss. Lytic lesions, a hallmark of this cancer, can result in significant morbidity because of associated pain and structural osseous compromise. Osteoplasty has demonstrated efficacy in the treatment of myelomatous pain within the axial skeleton; however, there is limited evidence supporting the utility of osteoplasty to treat extra-spinal lesions. We describe a 67 year-old woman with stable IgA lambda multiple myeloma with sentinel bilateral greater trochanteric lytic lesions that was referred to our interventional pain management clinic for evaluation of bilateral lateral hip pain. Conservative treatment options including physical therapy, non-steroidal anti-inflammatory drugs (NSAIDs), oral opiates, and local corticosteroid injections to bilateral trochanteric bursae failed to offer pain relief. The patient underwent minimally invasive percutaneous trochanteroplasty with concomitant core biopsy of her bilateral trochanteric lytic lesions. The intended goals of this novel procedure were to determine the cause of the suspected lytic lesions, provide pain relief, and offer structural stability by safely implanting bone cement as part of a fracture prevention strategy. At 12 month follow-up, the patient's pain improved by 70% and she no longer required the use of pain medication. The patient also displayed a significant improvement in her day-to-day functioning and quality of life.

摘要

多发性骨髓瘤是一种与骨质破坏相关的血液系统恶性肿瘤。溶骨性病变是这种癌症的一个标志,由于相关疼痛和骨结构受损,可导致显著的发病率。骨成形术已证明对治疗轴向骨骼的骨髓瘤性疼痛有效;然而,支持骨成形术治疗脊柱外病变效用的证据有限。我们描述了一名67岁女性,患有稳定的IgA λ型多发性骨髓瘤,双侧股骨大转子有前哨溶骨性病变,因双侧髋关节外侧疼痛被转诊至我们的介入疼痛管理诊所进行评估。包括物理治疗、非甾体抗炎药(NSAIDs)、口服阿片类药物以及双侧转子滑囊局部注射皮质类固醇在内的保守治疗方案均未能缓解疼痛。该患者接受了微创经皮转子成形术,并对双侧转子溶骨性病变进行了核心活检。这一创新手术的预期目标是确定疑似溶骨性病变的病因,缓解疼痛,并通过安全植入骨水泥作为骨折预防策略的一部分提供结构稳定性。在12个月的随访中,患者的疼痛改善了70%,不再需要使用止痛药物。患者的日常功能和生活质量也有显著改善。

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