Wladis Edward J, Levin Flora, Shinder Roman
*Ophthalmic Plastic Surgery, Department of Ophthalmology, Lions Eye Institute, Albany Medical College, Slingerlands, New York, U.S.A.; †Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, U.S.A.; and ‡Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York, U.S.A.
Ophthalmic Plast Reconstr Surg. 2015 Nov-Dec;31(6):467-9. doi: 10.1097/IOP.0000000000000390.
To describe the clinical features associated with periorbital necrotizing fasciitis and to correlate these features with clinical outcomes.
The case logs of 3 surgeons were used to identify cases of necrotizing fasciitis. Chart reviews were performed to characterize clinical metrics, and statistical analyses were performed.
Seventeen patients (9 males, 8 females; mean age = 48.1 years, standard deviation = 22.6 years) were identified with periorbital necrotizing fasciitis. Of these patients, 52.9% did not have immunodeficiencies, and 52.9% did not have antecedent trauma or infected facial lesions. One patient died from necrotizing fasciitis. A history of immunosuppression correlated with the requirement for exenteration, but did not correlate visual acuity of worse than 20/40 upon discharge from the hospital. Most of the patients (68.75%) were discharged with visual acuity of better than 20/40 in the affected eye.
This study represents the largest case series of patients with periorbital necrotizing fasciitis. Most of the patients in this series did not have immunodeficiencies, and the majority were discharged with favorable visual acuities. Nonetheless, a history of immunosuppression correlated with the need for exenteration, but was not statistically linked with worse visual outcomes.
描述与眶周坏死性筋膜炎相关的临床特征，并将这些特征与临床结果相关联。
使用3位外科医生的病例记录来识别坏死性筋膜炎病例。进行病历审查以描述临床指标，并进行统计分析。
确定了17例眶周坏死性筋膜炎患者（9例男性，8例女性；平均年龄 = 48.1岁，标准差 = 22.6岁）。在这些患者中，52.9%没有免疫缺陷，52.9%没有先前的创伤或面部感染性病变。1例患者死于坏死性筋膜炎。免疫抑制史与眼球摘除术的需求相关，但与出院时视力差于20/40无关。大多数患者（68.75%）出院时患眼视力优于20/40。
本研究是眶周坏死性筋膜炎患者最大的病例系列。该系列中的大多数患者没有免疫缺陷，并且大多数患者出院时视力良好。尽管如此，免疫抑制史与眼球摘除术的需求相关，但与较差的视力结果没有统计学关联。
