Tiyapanjanit Teeranun, Boonyavarakul Apussanee
J Med Assoc Thai. 2014 Nov;97(11):1151-6.
Rapid glucose fluctuations over daily period play an important role on diabetic complications.
To compare glycemic variability, mean plasma glucose, number ofcapillary blood glucose tests, and cost between the Phramongkutklao's diabetic formula and commercial diabetic formula in continuous tube fed patients with stable condition in type 2 diabetes.
A cross-over design study was performed between October 2010 and February 2011 in the medical department in Phramongkutklao Hospital. The researchers enrolled type 2 diabetic patients with stable condition who were on continuous tube fed. Seventy-two-hour continuous subcutaneous glucose monitoring was performed in all patients. Comparison ofmean amplitude ofglycemic excursions (MAGE), mean plasma glucose, cost, and number of capillary blood glucose tests were analyzed by using non-parametric Wilcoxon signed-rank test. Significance was defined as p<0.05. Results: Ten subjects were included in the present study. The Phramongkutklao's Diabetic Formula resulted in significantly lower mean plasma glucose (122±26.25 vs. 144.68±36.91 mg/dL, p = 0.022), cost (550.1±33.57 vs. 797.81±42.29 baht, p = 0.004), and number of capillary blood glucose tests (5±0.94 vs. 5.3±0.82 times, p = 0.083) when compared with commercial diabetic formula, but no significant difference in MAGE level (5.86±2.78 vs. 7.71±4.34 mg/dL, p = 0.333).
The Phramongkutklao's diabetic formula has significantly lower mean plasma glucose, less number of capillary blood glucose tests, and is less expensive than commercial diabetic formula. The glucose variability (MAGE) of the Phramongkutklao diabetic formula has also less than commercial diabetic formula, but does not reach statistical significance. The level ofplasma glucose was lower than 180 mg/dL in both formulas.
每日快速的血糖波动在糖尿病并发症中起重要作用。
比较在2型糖尿病病情稳定的持续管饲患者中，诗里蒙坤贴医院糖尿病配方与市售糖尿病配方在血糖变异性、平均血浆葡萄糖、毛细血管血糖检测次数及成本方面的差异。
2010年10月至2011年2月在诗里蒙坤贴医院内科进行了一项交叉设计研究。研究人员纳入了病情稳定的持续管饲2型糖尿病患者。对所有患者进行了72小时的持续皮下血糖监测。采用非参数Wilcoxon符号秩检验分析血糖波动平均幅度（MAGE）、平均血浆葡萄糖、成本及毛细血管血糖检测次数的差异。显著性定义为p<0.05。结果：本研究纳入了10名受试者。与市售糖尿病配方相比，诗里蒙坤贴医院糖尿病配方的平均血浆葡萄糖显著更低（122±26.25 vs. 144.68±36.91mg/dL，p = 0.022）、成本更低（550.1±33.57 vs. 797.81±42.29泰铢，p = 0.004）以及毛细血管血糖检测次数更少（5±0.94 vs. 5.3±0.82次，p = 0.083），但MAGE水平无显著差异（5.86±2.78 vs. 7.71±4.34mg/dL，p = 0.333）。
诗里蒙坤贴医院糖尿病配方的平均血浆葡萄糖显著更低，毛细血管血糖检测次数更少，且比市售糖尿病配方成本更低。诗里蒙坤贴医院糖尿病配方的血糖变异性（MAGE）也低于市售糖尿病配方，但未达到统计学显著性。两种配方的血浆葡萄糖水平均低于180mg/dL。
