Dhuvad Jigar, Patel Brijesh, Madan Sonal, Dhuvad Mukesh
Indian J Tuberc. 2014 Oct;61(4):325-30.
The aim of this study was to evaluate the clinical characteristics of orofacial lesions like ulcer, swelling, discharge (with or without fistulae), nodules (tubercles), granulomatous growth, induration, diffuse inflammation, and extraction socket involvement in an Indian population through the case reports and review of literature.
Four case reports are presented of patients who had orofacial lesions which turned out to be tuberculous. The diagnosis of tuberculosis was possible because it was kept high on the list of differential diagnosis of orofacial lesions. In our study, we used the following clinical criteria: 1) Suspicious lymph nodes should be biopsied. 2) Excision of non-healing, fistulous, or non-responsive lesions should be considered for biopsy. 3) Histopathological evidence of granulomatous inflammation with epithelioid cells and Langhan's giant cells or acid-fast bacilli should on Ziehl-Neelsen staining. 4) The patients' medical records were reviewed for details relating to presenting signs and symptoms, site and appearance of the lesions, chest x-ray findings, and sputum smear and tuberculosis culture results.
In all cases, the patients were prescribed antituberculosis therapy (ATT) by the physician. Strict follow-up was done to ensure completion of intensive phase therapy and both oral as well as pulmonary lesions were resolved.
Dentists and physicians treating orofacial lesions should be alert to the possibility of orofacial tuberculosis. Medical history should be taken very carefully and lymph node biopsy as well as other radiological and microbiological investigations should be carried out to rule out oral tuberculosis. Antituberculous therapy leads to successful resolution of the orofacial lesions.
本研究旨在通过病例报告和文献综述,评估印度人群中口腔溃疡、肿胀、分泌物(伴或不伴瘘管)、结节(结核结节)、肉芽肿性生长、硬结、弥漫性炎症及拔牙创受累等口腔颌面部病变的临床特征。
呈现4例口腔颌面部病变最终确诊为结核的患者病例报告。由于将结核病列为口腔颌面部病变鉴别诊断的重要考虑因素,因此得以确诊。在我们的研究中,采用了以下临床标准:1)对可疑淋巴结进行活检。2)对于不愈合、有瘘管或无反应的病变,应考虑切除活检。3)齐-尼氏染色显示有上皮样细胞、朗汉斯巨细胞或抗酸杆菌的肉芽肿性炎症的组织病理学证据。4)查阅患者病历,了解有关就诊时的体征和症状、病变部位和外观、胸部X线检查结果以及痰涂片和结核培养结果的详细信息。
所有病例中,医生均为患者开具了抗结核治疗(ATT)。进行了严格的随访,以确保强化期治疗完成,口腔及肺部病变均得到缓解。
治疗口腔颌面部病变的牙医和医生应警惕口腔颌面部结核的可能性。应仔细询问病史,并进行淋巴结活检以及其他放射学和微生物学检查,以排除口腔结核。抗结核治疗可成功治愈口腔颌面部病变。