Durcan M J, Hilakivi L A, Lister R G, Linnoila M
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
Alcohol. 1989 May-Jun;6(3):189-92. doi: 10.1016/0741-8329(89)90017-7.
In a social behavior test in mice ethanol (2 g/kg) significantly reduces the time spent in social interaction and increases locomotor activity. The relatively selective alpha 2-adrenoceptor antagonists atipamezole and idazoxan alone have no significant effect on either social interaction or locomotor activity in this test. However, when coadministered with 2 g/kg ethanol, atipamezole (0.3-3.0 mg/kg) significantly attenuated the ethanol-induced reduction in the time spent in social interaction without any effect on ethanol's locomotor stimulant action. Idazoxan (0.3-1.0 mg/kg) also showed a trend towards reversing the reduction in the time spent in social interaction although this was accompanied by a significant attenuation of the locomotor stimulant effect of ethanol. The results indicate that alpha 2-adrenoceptors may modulate ethanol's effects on social interaction in mice.
在一项针对小鼠的社会行为测试中，乙醇（2克/千克）显著减少了社交互动时间，并增加了运动活性。相对选择性的α2-肾上腺素能受体拮抗剂阿替美唑和异唑肼单独使用时，在该测试中对社交互动或运动活性均无显著影响。然而，当与2克/千克乙醇共同给药时，阿替美唑（0.3 - 3.0毫克/千克）显著减弱了乙醇诱导的社交互动时间减少，且对乙醇的运动刺激作用没有影响。异唑肼（0.3 - 1.0毫克/千克）也显示出逆转社交互动时间减少的趋势，尽管这伴随着乙醇运动刺激作用的显著减弱。结果表明，α2-肾上腺素能受体可能调节乙醇对小鼠社交互动的影响。
