Hunter D N, Gray H, Mudaliar Y, Morgan C, Evans T W
Intensive Care Unit, Brompton Hospital, London, U.K.
Int J Cardiol. 1989 Jun;23(3):365-71. doi: 10.1016/0167-5273(89)90197-6.
We studied the effects of dopexamine hydrochloride in 14 patients following cardiopulmonary bypass for coronary revascularisation (12 patients) or valve replacement (2 patients). The drug was administered by intravenous infusion at rates of 1, 2, 4 and 6 micrograms/kilogram/minute for a period of 10 minutes at each dose. Measurements of heart rate, blood pressure, right atrial pressure, pulmonary arterial pressure, pulmonary arterial wedge pressure and cardiac output (thermodilution method) were made at the end of each period. There were significant increases in heart rate (P less than 0.05), cardiac index (P less than 0.05) and systolic blood pressure (P less than 0.05). There were significant falls in systemic vascular resistance (P less than 0.05) and pulmonary vascular resistance (P less than 0.05). There were no significant changes in pulmonary arterial or wedge pressure. No serious adverse effects were observed. Dopexamine hydrochloride appears to be a useful supportive agent in patients following cardiopulmonary bypass, although further trials need to be carried out in order to establish precise therapeutic indications for its use.
我们研究了盐酸多培沙明对14例接受冠状动脉血运重建术（12例）或瓣膜置换术（2例）后体外循环患者的影响。通过静脉输注以1、2、4和6微克/千克/分钟的速率给药，每个剂量持续10分钟。在每个时间段结束时测量心率、血压、右心房压、肺动脉压、肺动脉楔压和心输出量（热稀释法）。心率（P<0.05）、心脏指数（P<0.05）和收缩压（P<0.05）有显著升高。全身血管阻力（P<0.05）和肺血管阻力（P<0.05）有显著下降。肺动脉压或楔压无显著变化。未观察到严重不良反应。盐酸多培沙明似乎是体外循环后患者有用的支持药物，尽管需要进行进一步试验以确定其确切的治疗适应证。
