Falavarjani Khalil Ghasemi, Aghamirsalim Mohammadreza, Modarres Mehdi, Hadavandkhani Ali, Hashemi Masih, Parvaresh Mohammad Mehdi, Naseripour Masood, Samiy Nasrollah
Department of Ophthalmology, Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences.
Department of Ophthalmology, Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences.
Can J Ophthalmol. 2015 Feb;50(1):33-6. doi: 10.1016/j.jcjo.2014.09.005.
To evaluate the rate of acute endophthalmitis after resident-performed intravitreal bevacizumab (IVB) injections and to compare the results with those performed by attending retina surgeons.
Retrospective comparative case series.
Eight thousand thirty-seven patients treated with intravitreal injection of bevacizumab.
A retrospective chart review of the resident-performed IVB injections at Rassoul Akram Hospital and attending-performed IVB injections at a private eye clinic between 2011 and 2014 was undertaken. Cases of clinical endophthalmitis were identified.
During the study interval, the overall incidence rate of postinjection endophthalmitis was 0.01% (1/8037). Antibiotic eye drops were prescribed after IVB injection for 2771 eyes (34.5%). The single case of acute endophthalmitis occurred after a resident-performed injection, and vitreous culture showed growth of Staphylococcus epidermidis. The incidence rate of acute endophthalmitis after resident-performed IVB injection was 0.02% (1/4921). No statistically significant difference was found in the rates of endophthalmitis between resident-performed and attending-performed injections (p = 1). Also, the difference in the rates of endophthalmitis between those receiving postinjection antibiotics and those who did not was not statistically significant (p = 0.3).
The risk for endophthalmitis after resident-performed IVB injection is low and similar to that of the supervising surgeons performing the procedure.
评估住院医师进行玻璃体内注射贝伐单抗（IVB）后急性眼内炎的发生率，并将结果与视网膜主治医生进行的注射结果进行比较。
回顾性比较病例系列。
8037例接受玻璃体内注射贝伐单抗治疗的患者。
对2011年至2014年间在拉苏勒·阿克拉姆医院由住院医师进行的IVB注射以及在一家私立眼科诊所由主治医生进行的IVB注射进行回顾性病历审查。确定临床眼内炎病例。
在研究期间，注射后眼内炎的总体发生率为0.01%（1/8037）。IVB注射后，2771只眼（34.5%）开具了抗生素眼药水。唯一一例急性眼内炎发生在住院医师进行注射后，玻璃体培养显示表皮葡萄球菌生长。住院医师进行IVB注射后急性眼内炎的发生率为0.02%（1/4921）。住院医师进行的注射与主治医生进行的注射之间的眼内炎发生率无统计学显著差异（p = 1）。此外，接受注射后抗生素治疗的患者与未接受治疗的患者之间的眼内炎发生率差异无统计学意义（p = 0.3）。
住院医师进行IVB注射后发生眼内炎的风险较低，与进行该操作的指导医生的风险相似。
