循环往复引领你抵达某处：果蝇卵室伸长过程中的集体细胞迁移与平面极性
Round and round gets you somewhere: collective cell migration and planar polarity in elongating Drosophila egg chambers.
作者信息
Cetera Maureen, Horne-Badovinac Sally
机构信息
Department of Molecular Genetics and Cell Biology, Committee on Development, Regeneration and Stem Cell Biology, The University of Chicago, 920 East 58(th) Street, Chicago, IL 60637, United States.
Department of Molecular Genetics and Cell Biology, Committee on Development, Regeneration and Stem Cell Biology, The University of Chicago, 920 East 58(th) Street, Chicago, IL 60637, United States.
出版信息
Curr Opin Genet Dev. 2015 Jun;32:10-5. doi: 10.1016/j.gde.2015.01.003. Epub 2015 Feb 9.
Planar polarity is a developmental mechanism wherein individual cell behaviors are coordinated across a two-dimensional plane. A great deal of attention has been paid to the roles that the Frizzled/Strabismus and Fat/Dachsous signaling pathways play in this process; however, it is becoming increasingly clear that planar polarity can also be generated through alternate mechanisms. This review focuses on an unconventional form of planar polarity found within the follicular epithelium of the Drosophila egg chamber that helps to create the elongated shape of the egg. We highlight recent studies showing that the planar polarity in this system arises through collective migration of the follicle cells and the resulting rotational motion of the egg chamber.
平面极性是一种发育机制，其中单个细胞的行为在二维平面上得到协调。人们已经高度关注了卷曲蛋白/斜视蛋白和脂肪/腊肠蛋白信号通路在这一过程中所起的作用；然而，越来越明显的是，平面极性也可以通过其他机制产生。本综述聚焦于在果蝇卵室的卵泡上皮细胞中发现的一种非常规形式的平面极性，这种极性有助于形成卵的细长形状。我们着重介绍了最近的研究，这些研究表明该系统中的平面极性是通过卵泡细胞的集体迁移以及由此产生的卵室旋转运动而产生的。
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