Woodman C B, Williams D, Yates M, Tomlinson K, Ward K, Luesley D
Department of Social Medicine, Medical School, Edgbaston, Birmingham.
Lancet. 1989 Jul 8;2(8654):88-90. doi: 10.1016/s0140-6736(89)90324-3.
A case-control comparison of adequate and inadequate cervical smears (adequacy being defined as the successful detection of cervical intraepithelial neoplasia and inadequacy as the failure to do so when disease was almost certainly present) was undertaken to determine whether indicators of effective cytological sampling could be identified. The association between inadequate smears and the absence of two types of normal epithelial cells (columnar cells of endocervical origin and immature metaplastic cells) was measured. A significant and substantial association was found between inadequate cervical smears and immature metaplastic cells and between inadequate smears and both types of cell. Endocervical cells alone were less likely to be found in inadequate than in adequate smears, but this association was not statistically significant.
进行了一项病例对照研究，比较宫颈涂片充分与不充分的情况（充分定义为成功检测到宫颈上皮内瘤变，不充分定义为在几乎肯定存在疾病时未能检测到），以确定是否能识别有效的细胞学采样指标。测量了不充分涂片与两种正常上皮细胞（宫颈管来源的柱状细胞和未成熟化生细胞）缺失之间的关联。发现宫颈涂片不充分与未成熟化生细胞之间以及不充分涂片与两种细胞之间存在显著且实质性的关联。仅宫颈管细胞在不充分涂片中比在充分涂片中更不易被发现，但这种关联无统计学意义。
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