Cytopathology. 1999 Feb;10(1):16-24.
Fifty-six slides, predominantly inadequate and of varying difficulty, were circulated to 12 laboratories as an educationally based slide exchange scheme. Three slides failed to achieve an agreed majority consensus opinion. Seventy percent of participants agreed with the consensus opinion in 80% of slides. Of the slides originally reported as inadequate, the consensus diagnosis was inadequate in 78%, negative in 12% and abnormal in 10%. The latter included two cases of high-grade dyskaryosis. There was good agreement for the two most frequent causes of inadequacy in submitted slides (obscured and poor cellularity). There was poor consistency in reporting the presence or absence of endocervical and immature squamous metaplastic cells, to an extent that questions their use in the assessment of smear adequacy. Three inadequate slides on consensus opinion were associated with subsequent cervical intraepithelial neoplasia (grade III) or invasive squamous cell carcinoma. In the latter case, the slide had originally been reported as negative by the submitting laboratory.
作为一项基于教育目的的玻片交换计划，向12个实验室分发了56张玻片，这些玻片大多质量欠佳且难度各异。有3张玻片未能达成一致的多数共识意见。70%的参与者在80%的玻片上同意共识意见。在最初报告为质量欠佳的玻片中，78%的玻片共识诊断为质量欠佳，12%为阴性，10%为异常。后者包括2例高级别核异质病例。对于提交的玻片中最常见的两个质量欠佳原因（视野模糊和细胞数量少），存在良好的一致性。在报告宫颈管和未成熟鳞状化生细胞的有无方面，一致性较差，以至于对它们在涂片质量评估中的用途提出了质疑。根据共识意见，3张质量欠佳的玻片与随后的宫颈上皮内瘤变（III级）或浸润性鳞状细胞癌相关。在后一种情况下，提交实验室最初将该玻片报告为阴性。
