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一种罕见淋巴瘤中的外周血噬血细胞现象。

Peripheral blood hemophagocytosis in an unusual lymphoma.

作者信息

Fragasso Alberto, Mannarella Clara, Ciancio Angela, Scarciolla Oronzo

机构信息

Hematology Unit, Ospedale Madonna delle Grazie, ASM Matera, Italy.

出版信息

Clin Case Rep. 2015 Jan;3(1):11-3. doi: 10.1002/ccr3.124. Epub 2014 Dec 2.

DOI:10.1002/ccr3.124
PMID:25678965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4317203/
Abstract

We describe a patient with fever, pancytopenia, and hepato-splenomegaly associated with the finding of neoplastic lymphoid cells and histiocytes with hemophagocytosis in the peripheral smear; the diagnostic features were suggestive for a biological overlap between a large B-cell lymphoma with intravascular involvement and the Asian variant of intravascular B-cell lymphoma.

摘要

我们描述了一名患者，其伴有发热、全血细胞减少和肝脾肿大，在外周血涂片检查中发现了肿瘤性淋巴细胞和具有噬血细胞现象的组织细胞；诊断特征提示血管内受累的大B细胞淋巴瘤与血管内B细胞淋巴瘤亚洲变种之间存在生物学重叠。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f828/4317203/39eee10f3979/ccr30003-0011-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f828/4317203/9cb084fd6420/ccr30003-0011-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f828/4317203/39eee10f3979/ccr30003-0011-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f828/4317203/9cb084fd6420/ccr30003-0011-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f828/4317203/39eee10f3979/ccr30003-0011-f2.jpg

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本文引用的文献

1
Intravascular large B-cell lymphoma--a diagnostic dilemma.血管内大B细胞淋巴瘤——诊断难题
Clin Lymphoma Myeloma Leuk. 2013 Dec;13(6):e18-21. doi: 10.1016/j.clml.2013.07.001. Epub 2013 Sep 20.
2
The labyrinth of pyrexia of unknown origin: a case of intravascular diffuse B cell lymphoma.发热待查的迷宫：弥漫性血管内 B 细胞淋巴瘤 1 例。
Mediterr J Hematol Infect Dis. 2013;5(1):e2013019. doi: 10.4084/MJHID.2013.019. Epub 2013 Feb 20.
3
Intravascular large B-cell lymphoma with hemophagocytic syndrome (Asian variant) in a Caucasian patient.
一名白种人患者患血管内大B细胞淋巴瘤伴噬血细胞综合征（亚洲变异型）。
Int J Clin Exp Pathol. 2012;5(5):448-54. Epub 2012 May 23.
4
Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting.血管内大B细胞淋巴瘤的定义、诊断与管理：一项国际共识会议的提议与观点
J Clin Oncol. 2007 Jul 20;25(21):3168-73. doi: 10.1200/JCO.2006.08.2313. Epub 2007 Jun 18.
5
Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions.不同地理区域诊断出的血管内淋巴瘤在临床表现、噬血细胞增多频率及临床行为方面的差异。
Haematologica. 2007 Apr;92(4):486-92. doi: 10.3324/haematol.10829.
6
Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases.具有独特脾脏和骨髓受累模式的弥漫性大B细胞淋巴瘤：2例临床病理特征
Mod Pathol. 2005 Apr;18(4):495-502. doi: 10.1038/modpathol.3800297.
7
Intravascular large B-cell lymphoma with bone marrow involvement at presentation and haemophagocytic syndrome: two Western cases in favour of a specific variant.初诊时伴有骨髓受累及噬血细胞综合征的血管内大B细胞淋巴瘤：两例支持特定亚型的西方病例
Histopathology. 2000 Dec;37(6):509-12. doi: 10.1046/j.1365-2559.2000.00980.x.