Biglari Bahram, Reitzel Tim, Swing Tyler, Büchler Axel, Gerner Hans Jürgen, Schmidmaier Gerhard, Moghaddam Arash
Bahram Biglari, MD, is Chief Physician, Department of Paraplegiology, Ludwig-Guttmann-Str, Heidelberg, Germany. Tim Reitzel, MD, is a Physician, Department of Paraplegiology, BG Trauma Center, Ludwig-Guttmann-Str, Ludwigshafen, Germany. Tyler Swing is a Medical Student, Trauma and Reconstructive Surgery, Department of Orthopedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Germany. Axel Büchler, MD, is a Physician; Hans Jürgen Gerner, MD, is a Physician and Professor; Gerhard Schmidmaier, MD, is a Physician and Professor; and Arash Moghaddam, MD, is a Physician, all at Trauma and Reconstructive Surgery, Department of Orthopedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital.
Adv Skin Wound Care. 2015 Mar;28(3):123-8. doi: 10.1097/01.ASW.0000459845.95441.1a.
To determine the effectiveness of platelet-rich plasma (PRP) in the treatment of nonhealing fistula in spinal cord-injured patients.
This was a pilot study of 15 spinal cord-injured patients with chronic pressure ulcers (PrUs) and nonhealing fistulas treated with PRP.
Germany, Rheinland Pfalz, BG Trauma Center Ludwigshafen
The authors treated 15 patients with PRP who had nonhealing fistulas due to multiple surgical closures of PrUs. According to the National Pressure Ulcer Advisory Panel's stages, 12 patients had Stage III PrUs, and 3 patients had Stage IV PrUs.
After 1 week of treatment with PRP, the authors observed low levels of secretion from the fistulas. After 2 weeks, they noted no further secretion from the fistulas. A magnetic resonance imaging control investigation after 3 weeks showed the complete disappearance of the fistulas. No negative effects and no allergic reactions were noted in the use of PRP.
The authors' results suggest that the application of PRP in combination with debridement is an effective therapy option and good alternative to recurrent surgical interventions for treating nonhealing fistulas resulting from the surgical closure of PrUs.
确定富血小板血浆（PRP）治疗脊髓损伤患者不愈合瘘管的有效性。
这是一项针对15例脊髓损伤患者的初步研究，这些患者患有慢性压疮（PrUs）且不愈合瘘管，接受了PRP治疗。
德国莱茵兰-普法尔茨州路德维希港BG创伤中心
作者对15例因PrUs多次手术闭合导致不愈合瘘管的患者进行了PRP治疗。根据国家压疮咨询小组的分期，12例患者为III期PrUs，3例患者为IV期PrUs。
用PRP治疗1周后，作者观察到瘘管分泌物减少。2周后，他们注意到瘘管不再有分泌物。3周后的磁共振成像对照检查显示瘘管完全消失。使用PRP时未观察到负面影响和过敏反应。
作者的结果表明，PRP联合清创术的应用是一种有效的治疗选择，是治疗因PrUs手术闭合导致的不愈合瘘管反复手术干预的良好替代方法。
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