Hu Huayou, Tian Jiaxin, Liu Yun, Liu Yong, Shi Fei, Wang Xiang, Kan Yuhe, Wang Chao
Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University , Huaian 223300, P. R. China.
J Org Chem. 2015 Mar 6;80(5):2842-7. doi: 10.1021/jo502823m. Epub 2015 Feb 23.
A palladium-catalyzed oxidative amination protocol of electron-deficient olefins by aza-Wacker-type reaction with N-alkylsulfonamides was developed. The presence of the stoichiometric amount of methanesulfonic acid was crucial for the success of this transformation. The reactions were conducted in green solvent under mild conditions and scalable with excellent E-type stereoselectivity. In addition, a Pd(II)/Pd(0) catalytic cycle with the existence of a very strong oxidant (Selectfluor) was proposed.
开发了一种通过与N-烷基磺酰胺进行氮杂瓦克型反应，对缺电子烯烃进行钯催化氧化胺化的方法。化学计量的甲磺酸的存在对该转化的成功至关重要。反应在绿色溶剂中于温和条件下进行，且可扩大规模，并具有出色的E型立体选择性。此外，还提出了一种存在极强氧化剂（Selectfluor）的Pd(II)/Pd(0)催化循环。
