Wolff Jean, Komura Shigeyuki, Andelman David
Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, B.P. 84047, 67034 Strasbourg Cedex 2, France and Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.
Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Tokyo 192-0397, Japan.
Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Jan;91(1):012708. doi: 10.1103/PhysRevE.91.012708. Epub 2015 Jan 20.
We propose a model that accounts for the budding behavior of domains in lipid bilayers, where each of the bilayer leaflets has a coupling between its local curvature and the local lipid composition. The compositional asymmetry between the two monolayers leads to an overall spontaneous curvature. The membrane free energy contains three contributions: the bending energy, the line tension, and a Landau free energy for a lateral phase separation. Within a mean-field treatment, we obtain various phase diagrams which contain fully budded, dimpled, and flat states. In particular, for some range of membrane parameters, the phase diagrams exhibit a tricritical behavior as well as a three-phase coexistence region. The global phase diagrams can be divided into three types and are analyzed in terms of the curvature-composition coupling parameter and domain size.
我们提出了一个解释脂质双层中结构域出芽行为的模型，其中双层的每个小叶在其局部曲率和局部脂质组成之间存在耦合。两个单层之间的组成不对称导致了整体的自发曲率。膜自由能包含三个部分：弯曲能、线张力以及横向相分离的朗道自由能。在平均场处理下，我们得到了包含完全出芽、凹陷和平坦状态的各种相图。特别地，对于某些膜参数范围，相图表现出三临界行为以及三相共存区域。全局相图可分为三种类型，并根据曲率 - 组成耦合参数和结构域大小进行分析。
