[实验性梗死犬心肌不同部位的环核苷酸系统]

[The cyclic nucleotide system in various sections of the dog myocardium in experimental infarction].

作者信息

Frolova N Iu, Printsev M D, Tret'iakov A V, Kozhetiakin L A, Korovkin B F

出版信息

Vopr Med Khim. 1989 Jan-Feb;35(1):64-8.

Abstract

Distinct increase and then decrease in content of cyclic nucleotides was observed in dog myocardium ventricles and auricles within early periods of heart infarction (10 min-4 hrs). Within a day after ligation of artery the ratio cAMP/cGMP was considerably decreased as a result of activation of guanylate cyclase and cAMP-phosphodiesterase as well as due to a decrease in activity of adenylate cyclase. Acute ischemia of small area of the heart left ventricle caused impairment of cyclic nucleotide metabolism in all the heart muscle.

摘要

在心肌梗死早期（10分钟至4小时），犬心室和心房中的环核苷酸含量出现明显先升高后降低的情况。动脉结扎后一天内，由于鸟苷酸环化酶和环磷酸腺苷磷酸二酯酶的激活以及腺苷酸环化酶活性降低，环磷酸腺苷/环磷酸鸟苷的比值显著下降。心脏左心室小面积的急性缺血导致整个心肌中环核苷酸代谢受损。

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