人黑色素瘤细胞匀浆中的腺苷酸环化酶活性。α-促黑素细胞激素和异丙肾上腺素的作用。
Adenylate cyclase activity in homogenates of human melanoma cells. Effect of alpha-MSH and isoprenaline.
作者信息
Karg E, Johansson L H, Hindemith-Augustsson A, Rosengren E, Rorsman H
机构信息
Department of Dermatology, University of Lund, Sweden.
出版信息
Acta Derm Venereol. 1989;69(4):288-91.
The effects of the alpha-melanocyte-stimulating hormone (alpha-MSH) (10(-7)-10(-5) M) and the beta-adrenoceptor agonist isoprenaline (10(-9)-10(-4) M) on adenylate cyclase (AC) activity were investigated in homogenates of the human IGR 1 melanoma cells with or without additional GTP. Basal AC activity was increased by the administration of 10 microM GTP. Alpha-MSH had no effect on cyclic AMP (cAMP) accumulation, while isoprenaline stimulated AC activity in a dose-dependent manner.
研究了α-黑素细胞刺激素（α-MSH）（10^-7 - 10^-5 M）和β-肾上腺素能受体激动剂异丙肾上腺素（10^-9 - 10^-4 M）对添加或未添加额外鸟苷三磷酸（GTP）的人IGR 1黑色素瘤细胞匀浆中腺苷酸环化酶（AC）活性的影响。给予10微摩尔/升GTP可增加基础AC活性。α-MSH对环磷酸腺苷（cAMP）积累无影响，而异丙肾上腺素以剂量依赖性方式刺激AC活性。
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