动物细胞中的胞质分裂。
Cytokinesis in animal cells.
作者信息
D'Avino Pier Paolo, Giansanti Maria Grazia, Petronczki Mark
机构信息
Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom.
Istituto di Biologia e Patologia Molecolari c/o Dipartimento di Biologia e Biotecnologie, Università Sapienza di Roma, 00185 Roma, Italy.
出版信息
Cold Spring Harb Perspect Biol. 2015 Feb 13;7(4):a015834. doi: 10.1101/cshperspect.a015834.
Abstract
Cell division ends with the physical separation of the two daughter cells, a process known as cytokinesis. This final event ensures that nuclear and cytoplasmic contents are accurately partitioned between the two nascent cells. Cytokinesis is one of the most dramatic changes in cell shape and requires an extensive reorganization of the cell's cytoskeleton. Here, we describe the cytoskeletal structures, factors, and signaling pathways that orchestrate this robust and yet highly dynamic process in animal cells. Finally, we discuss possible future directions in this growing area of cell division research and its implications in human diseases, including cancer.
摘要
细胞分裂以两个子细胞的物理分离而结束，这一过程称为胞质分裂。这一最终事件确保了细胞核和细胞质内容物在两个新生细胞之间准确分配。胞质分裂是细胞形状最显著的变化之一，需要对细胞的细胞骨架进行广泛的重组。在这里，我们描述了在动物细胞中协调这一强大而又高度动态过程的细胞骨架结构、因子和信号通路。最后，我们讨论了这个细胞分裂研究不断发展的领域未来可能的方向及其对包括癌症在内的人类疾病的影响。
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Dev Cell. 2014 Jun 9;29(5):547-561. doi: 10.1016/j.devcel.2014.04.021.
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GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.在黑腹果蝇的胞质分裂过程中，GOLPH3对于收缩环的形成以及Rab11定位到分裂位点至关重要。
PLoS Genet. 2014 May 1;10(5):e1004305. doi: 10.1371/journal.pgen.1004305. eCollection 2014 May.
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Dividing cells regulate their lipid composition and localization.细胞分裂调节其脂质组成和定位。
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