Gupta Rajib K, Patton Kurt T
Department of Pathology & Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Ave, 5th Floor, Memphis, TN 38163, USA.
Baptist Memorial Hospital, 6019 Walnut Grove, Memphis, TN 38120, USA; Pathology Group of the Midsouth/Trumbull Laboratories, 7550 Wolf River Blvd, Suite 200, Germantown, TN 38138, USA.
Hum Pathol. 2015 Apr;46(4):625-8. doi: 10.1016/j.humpath.2014.12.015. Epub 2015 Jan 29.
Hyalinizing cholecystitis (HC) is a recently described rare subtype of chronic cholecystitis characterized by dense, paucicellular collagenous transmural fibrosis, which usually replaces the mucosa and muscularis propria. Immunoglobulin (Ig)G4-associated cholecystitis is also a newly described cholecystitis variant characterized by transmural or extramural lymphoplasmacytic inflammation, lymphoid follicles, storiform fibrosis, phlebitis, and increased tissue IgG4-positive plasma cells. We describe a case of cholecystitis in an elderly white man who harbored features of both HC and IgG4-associated cholecystitis. In retrospect, the patient also had a significantly elevated serum IgG4 level. To the best of our knowledge, an association between HC and IgG4-related disease has not been previously described in the literature. Although not entirely conclusive, our observations raise the possibility that some cases of HC represent the end stage of IgG4-related disease.
玻璃样变性胆囊炎（HC）是一种最近描述的罕见的慢性胆囊炎亚型，其特征为致密、细胞稀少的胶原性透壁纤维化，通常取代黏膜和固有肌层。免疫球蛋白（Ig）G4相关性胆囊炎也是一种新描述的胆囊炎变体，其特征为透壁或壁外淋巴浆细胞炎症、淋巴滤泡、席纹状纤维化、静脉炎以及组织中IgG4阳性浆细胞增多。我们报告一例老年白人男性胆囊炎病例，该病例兼具HC和IgG4相关性胆囊炎的特征。回顾来看，该患者血清IgG4水平也显著升高。据我们所知，此前文献中尚未描述过HC与IgG4相关疾病之间的关联。尽管并非完全确凿，但我们的观察结果提示，某些HC病例可能代表IgG
