Lab of Traditional Chinese Medicine and Marine Drugs, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China.
Lab of Traditional Chinese Medicine and Marine Drugs, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China.
Environ Toxicol Pharmacol. 2015 Mar;39(2):515-24. doi: 10.1016/j.etap.2014.12.014. Epub 2015 Jan 30.
The poor bioavailability and stability of curcumin limit its clinical application. A novel Zn(II)-curcumin complex was synthesized and its effects against cyclophosphamide (CP)-induced reproductive damage were compared with curcumin. Oral administration of Zn(II)-curcumin significantly prevented CP-induced elevation of malondialdehyde (MDA) level and reductions in superoxide dismutase (SOD) activity and glutathione (GSH) content in mouse testis. Zn(II)-curcumin significantly ameliorated CP-induced reductions in body and reproductive organs weights. Zn(II)-curcumin dose-dependently ameliorated CP-induced reproductive system impairments, by improving sperm parameters (sperm count, viability, motility) and reducing serum testosterone and histological alterations. Compared to curcumin at the same dose, Zn(II)-curcumin more effectively alleviated CP-induced reproductive injury, leading to a reduced severity of testicular pathologic changes, lower MDA level, elevated SOD activity and GSH content, and increased sperm parameters and serum testosterone. These results suggest Zn(II)-curcumin more effectively protects against CP-induced reproductive damage than curcumin alone due to a synergistic reduction in oxidative stress.
姜黄素的生物利用度和稳定性差限制了其临床应用。本研究合成了一种新型的 Zn(II)-姜黄素配合物，并将其抗环磷酰胺 (CP) 诱导生殖损伤的效果与姜黄素进行了比较。口服 Zn(II)-姜黄素可显著预防 CP 诱导的小鼠睾丸丙二醛 (MDA) 水平升高和超氧化物歧化酶 (SOD) 活性及谷胱甘肽 (GSH) 含量降低。Zn(II)-姜黄素可显著改善 CP 诱导的体重和生殖器官重量降低。Zn(II)-姜黄素可剂量依赖性改善 CP 诱导的生殖系统损伤，提高精子参数（精子计数、活力、运动性），降低血清睾酮和组织学改变。与相同剂量的姜黄素相比，Zn(II)-姜黄素更有效地减轻 CP 引起的生殖损伤，降低睾丸病理变化的严重程度，降低 MDA 水平，提高 SOD 活性和 GSH 含量，增加精子参数和血清睾酮。这些结果表明，Zn(II)-姜黄素通过协同降低氧化应激，比单独使用姜黄素更有效地保护 CP 诱导的生殖损伤。
