胎儿黑质移植。对大鼠纹状体中多巴胺受体的影响。
Fetal substantia nigra grafts. Effect on dopamine receptors in the rat corpus striatium.
作者信息
Korfali E, Knowles W D, Uysal S, Ulus I H, Ozmen T
出版信息
Cleve Clin J Med. 1989 May;56(3):259-62. doi: 10.3949/ccjm.56.3.259.
Effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hydroxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7% increase of [3H]spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25% decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A nonsignificant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.
在用脑室注射6-羟基多巴胺破坏黑质纹状体多巴胺能通路后，研究了胎鼠黑质移植对大鼠纹状体中多巴胺受体的影响。与正常对照组大鼠相比，假移植大鼠纹状体中[3H]螺哌啶结合增加53.7%，证实了预期的多巴胺受体去神经超敏反应。相反，移植大鼠的超敏反应显著降低，与假移植组相比，移植侧尾状核的结合减少了25%。在未移植侧也观察到结合减少了15%，但差异不显著。因此，胎鼠黑质移植将去神经超敏反应降低到了正常水平。
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